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Given the serious consequences of unwanted pregnancy, the cautious approach of using additional or alternative contraception during short courses of broad-spectrum antibiotics and the initial weeks of long-term antibiotic administration may be justified to safeguard the few unidentifiable women who may be at risk.
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Two gene variants have been linked to an increased risk of hepatotoxicity of antituberculosis medications; NAT2 and CYP 2E1, but the associations require further confirmation).
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Pyridoxine should be given to all HIV-infected patients being treated for active TB, to reduce the risk of INH-associated neuropathy.
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Rare cases of pill-induced esophagitis and pseudomembranous colitis have been associated with the use of rifampin.
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Since many of these organisms are present in the environment isolation of these organisms from clinical specimens may represent colonisation and contamination and may not necessarily correlate with disease.
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ART within 2-4 weeks of TB treatment start was associated with a reduction of the combined endpoint of mortality and AIDS progression by 68% in SAPIT and 42% in STRIDE.
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In new patients with miliary TB without TB meningitis, nine months of anti-tuberculosis treatment should be adequate.
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The British Thoracic Society recommends 6 months of daily treatment with rifampicin and isoniazid, supplemented in the initial 2 months with pyrazinamide and either ethambutol or streptomycin (the 6-month four-drug regimen), irrespective of age.
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Mutations in the rifampicin resistance-determining region (RRDR) of the rpoB gene were identified in 17 isolates (94.
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